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The Most Effective Natural Antibiotic

(Finding the best natural antibiotic for specific conditions.)


The over-reliance on prescription antibiotics is an ongoing medical problem. In the news, we continue seeing scientists issuing concerns over treatment-resistant antibiotic strains, or “Superbugs.”

Some researchers are calling our overuse of antibiotic drugs “the Antibiotic Resistance Crisis”.

[Related Article: Top 9 Science-Backed Immune System Supplements]

While antibiotics were a breakthrough in modern medicine, some individuals cannot take them because of intolerable side effects.

Recently, we find more researchers complaining about the toxicity of antibiotics to the body. Aside from neurotoxic dangers, the ongoing focus around gut microbiome-related health should give us enormous apprehension over the long-term health costs of prescription antibiotics.

[Related Article: Top 9 Science-Backed Gastrointestinal Supplements]

Best Supplement for the Common Bacterial Infections

(* Denotes In Vitro Studies)

(**Denotes Animal Studies)

(Bold Denotes Strongest Evidence)

Acquired Hospital Infections


Nearly 500,00 cases of Clostridium difficile infections cause diarrhea in hospital patients, from one of the biggest drug-resistant bacterial infections, killing 14,000 while costing the US healthcare system $1 billion annually. Pseudomonas aeruginosa and Pseudomonas fluorescens are infections in those with low immunity. Klebsiella, the most common hospital pneumonia, causes blood and urinary tract infections.


Best Supplement Matches

Clostridium Difficile:

Echinacea, oil of oregano*, Lactobacillus reuteri (L. reuteri).

Klebsiella Pneumoniae:

Cinnamon oil + clove oil + oil of oregano*, curcumin**, ginger*, myrrh*, oil of oregano*, rosemary extract*.

Pseudomonas Aeruginosa:

Cinnamon oil + clove oil, ginger*, lemongrass extract*, manuka honey*, myrrh*, oil of oregano*, rosemary extract*, tea tree oil*, thyme oil.

Pseudomonas Fluorescent:

Oil of oregano*, thyme oil.


Oil of oregano gives a powerful performance in this category, as it does in most of them. Thyme oil is also an excellent option. Lactobacillus reuteri (L. reuteri) completely inhibits clostridium difficile.


Cavities and Gum Infections


Periodontal diseases affect 20–50% of the global population, with periodontitis gum disease being caused by Aggregatibacter actinomycetemcomitans. Tooth enamel-damaging dental plaque from Streptococcus mutans can cause cavities and gum disease.


Best Supplement Matches

Aggregatibacter Actinomycetemcomitans:


Streptococcus Mutans:

Garlic, manuka honey, oil of oregano*, oil of oregano**, tea tree oil*.


Garlic performs well in periodontal bacterial testing, as does manuka honey. Oil of oregano, and tea tree oil can also be useful. Newer studies show popular sweeteners including erythritol, monk fruit, stevia, and xylitol as potent natural oral antibiotics.


Food-Borne Infections


The world undergoes roughly 600 million cases of food-borne diseases, resulting in 420,000 deaths. We estimate almost one-third of these are children under the age of 5 years old. As Escherichia coli or E. coli is the primary food-borne bacteria, Campylobacter jejuni and Salmonella are other causes of food poisoning, which typically end with diarrhea.


Best Supplement Matches

E. Coli:

Cinnamon oil* + clove oil*, cinnamon oil* + clove oil + oil of oregano*, clove extract*, curcumin*, ginger*, lemongrass extract*, manuka honey*, myrrh*, oil of oregano*, olive leaf extract, rosemary extract or rosemary oil*, tea tree oil*, thyme extract or thyme oil*.


Cinnamon oil* + clove oil*, clove extract*, ginger*, lemongrass extract*, manuka honey*, myrrh*, oil of oregano + mustard oil + thyme oil*, oil of oregano*, olive leaf extract, rosemary extract or rosemary oil*, tea tree oil*, thyme extract or thyme oil*.

Campylobacter Jejuni:

Clove extract*, tea tree oil*.


The cinnamon, clove, and oil of oregano combination perform well in these studies.


Gastrointestinal Infections


Helicobacter pylori or H. pylori infection typically begins with childhood infection in the stomach. This pathogen lives in the upper gastrointestinal system causing stomach lining sores or peptic ulcers, which can lead to stomach cancer. Abdominal pain, belching, bleeding, bloating, fatigue, nausea, and vomiting are common symptoms. While 61% or 4.4 billion worldwide experience H. pylori infection, inflammatory gastritis does not always occur.


Best Supplement Matches

H. Pylori:

Cinnamon extract*, curcumin, curcumin**, ginger*, ginger extract**, honey + black/green tea.


Emerging evidence draws our attention to combining manuka honey with matcha green tea for H. pylori. Curcumin and ginger are synergistic together and can be a solid additional option.


Lower Respiratory Tract Infections (Pneumonia)


Causing an array of infections, Haemophilus influenzae can cause blood poisoning or septicemia, bronchitis, pneumonia, and other serious conditions. With 70,000 annual infections, Legionnaires’ disease is pneumonia caused by Legionella pneumophila, responsible for more deaths than any other water contaminants.


Best Supplement Matches

Haemophilus Influenzae:

Cinnamon oil*, clove oil*, thyme oil*.

Legionella Pneumophila:



A combination of echinacea, cinnamon, clove, and thyme seems to be the best supplement matches for pneumonia-based infections.


Small Intestine Bacterial Overgrowth (SIBO)


While not a transmitted infection, SIBO occurs when there is an excess in the growth of bacteria in the digestive system. Recent evidence shows natural compounds can be as effective as antibiotic drugs in the treatment of SIBO. The number of people with SIBO in the general population remains unknown.

We believe between 6 to 15% of healthy, asymptomatic people have SIBO, and 80% of those with irritable bowel syndrome (IBS) also have SIBO. Diamine oxidase (DAO) deficiency and mast cell activation syndrome (MCAS) increasing histamine intolerance might be responsible for SIBO and IBS.

We also associate SIBO with Crohn’s disease, fibromyalgia, hypothyroidism, liver cirrhosis, rheumatoid arthritis, rosacea, and ulcerative colitis.

Best Supplement Matches

Allicin extract from garlic, berberine or Indian barbarry root, coptis root, horsetail, lemon balm, oil of oregano, red thyme oil, wormwood has been effective in inhibiting bacterial growth.

Berberine, bromelain, butterbur, curcumin, green tea, neem, nettle, olive leaf extract, pau d’arco, quercetin are natural histamines which can increase DAO and respiratory system function.


Allicin, berberine, and oil of oregano contain the best evidence for SIBO. Quercetin, bromelain, stinging nettle, and butterbur bring the best evidence for supporting and increasing DAO activity.


Skin Infections


Propionibacterium acnes is the common cause of acne, affecting over 90% of humans at least once. Flesh-eating disease, or necrotizing fasciitis, is a sign of Streptococcus pyogenes.

While Staphylococcus aureus is typically on the skin, it can trigger a life-threatening heart infection, called infective endocarditis. The toxins created by Staphylococcus aureus and Streptococcus pyogenes bacteria cause toxic shock syndrome, a rare but fatal infection.

Skin and tissue infections are symptoms of Vibrio vulnificus, which are commonly the sign of underlying diseases such as liver damage or cirrhosis.

Best Supplement Matches

Propionibacterium Acnes:

Cinnamon extract*, echinacea, tea tree oil*.

Staphylococcus Aureus:

Cinnamon oil + clove oil*, clove extract*, garlic, ginger*, lemongrass extract*, manuka honey, manuka honey*, myrrh*, oil of oregano + mustard oil + thyme oil*, oil of oregano, red pepper (capsaicin)*, red pepper (capsaicin)**, rosemary extract or rosemary oil*, tea tree oil*.

Streptococcus Pyogenes:

Garlic, manuka honey*, red pepper (capsaicin)*.


Garlic, manuka honey, and tea tree oil offer the best evidence for skin infections.


Urinary Tract Infections


Urinary tract infections (UTIs) are some of the most common bacterial infections, annually affecting 150 million worldwide. While Serratia marcescens or Proteus mirabilis can cause urinary tract infections, E. coli and Enterococcus faecalis are primarily responsible for 90% of all infections.

Best Supplement Matches

Enterococcus Faecalis:

Cinnamon oil + clove oil*, hibiscus*, manuka honey*, oil of oregano*, thyme extract + thyme oil, cranberry, d-mannose, hibiscus extract.

Proteus mirabilis:

Cranberry, d-mannose, hibiscus extract.

Serratia marcescens:



D-mannose and hibiscus extract show effectiveness against multi-drug treatment-resistant strains. Often supplements will include these two with the lesser potent cranberry.


Sexually Transmitted Infections


Chlamydia and gonorrhea are the most common sexually transmitted bacterial infections. While some claim these types of infections can heal with natural compounds, the evidence is not reliable. Whether its apple cider vinegar, goldenseal, Listerine for gonorrhea, or one is suggesting garlic, echinacea, goldenseal, curcumin, or olive leaf extract for chlamydia, antibiotic drugs remain the only proven treatment.


Upper Respiratory Infections


Upper respiratory infections can be because of viral and bacterial pathogens. The distinction between the two is we can treat bacterial infections with antibiotics, whereas we cannot with viral infections.

The most common bacterial pathogens responsible for acute sinusitis are Streptococcus pneumonia. Moraxella catarrhalis, Staphylococcus aureus, and Streptococcus pyogenes are other bacterial pathogens involved in upper respiratory tract infections.


Garlic, manuka honey, and oregano oil show the best evidence against multi-drug treatment-resistant bacterial strains.


The Top 55 Overall Natural Antibiotics List:

1. Algae

2. Andrographis Paniculata

3. Anise

4. Avocado Oil

5. Berberine

6. Black Seed Oil

7. Bromelain

8. Cabbage

9. Caprylic Acid

10. Cinnamon

11. Clove

12. Colloidal Silver

13. Coconut Oil

14. Cranberry

15. D-mannose

16. Echinacea

17. Eucalyptus

18. Fermented Foods (Kombucha, Pickles, Sauer-kraut)

19. Garlic (Allicin)

20. Ginger

21. Ginseng

22. Goldenseal

23. Grapefruit Seed Extract

24. Green Tea

25. Hibiscus

26. Honey (Raw/ Manuka)

27. Horseradish

28. Lactobacillus reuteri (L. reuteri)

29. Lauric Acid

30. Lemongrass

31. MCT oil

32. Monolaurin

33. Moringa

34. Myrrh

35. NAC (N-Acetyl Cysteine)

36. Neem

37. Oil of Oregano

38. Olive leaf extract

39. Olive Oil

40. Onion (Chive/ Shallot)

41. Oregon Grape

42. Pau D’arco

43. Pepper (Black/ Red Capsaicin)

44. Probiotics

45. Quercetin

46. Rosemary

47. Stinging Nettle

48. Tea Tree Oil

49. Thyme

50. Turmeric (Curcumin)

51. Uva-Ursi

52. Vinegar (Apple Cider/ Coconut)

53. Vitamin C

54. Yogurt

55. Wine

Your Friend in Health

Mark Stein

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