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The 3 Most Affordable Health Optimization Supplements

For a total of $.27 per day: Consider These Power 3


“Everyone tells me you get what you pay for and if you want results, you need to pay for them.”

“Do highly affordable science-backed supplements exist?”

[Related Article: 5 Core Supplements for Every Health Optimizer]

I’m glad you asked this question because it’s an excellent one.

There are some meaningful cost-effective options, which you can use to optimize your health.

Methylation is a hot health topic, as up to 40% of people have one or two copies of a C677T or A1298C MTHFR gene variant, sometimes called a “mutation.”

This means many health issues by some might be started and/or worsened by methylation dysfunction.

One can think of methylation as the Grand Central Station of our cellular processes.

Methylation allows our body to work by switching on and off billions of times a day.

We use up 80% of SAMe, our primary methylation cycle donor or “regulator”, to make creatine and phosphatidylcholine.

Taking these two supplements ‘buffers” SAMe levels and supports methylation.

From the biggest return on investment, these three supplements we rank as the very best for overall health optimization.

Melatonin (Delayed-Release)

Melatonin is a sleep-wake cycle regulating hormone.

Levels of melatonin can drop in unhealthy individuals such as smokers or other variables, such as odd work cycles or lack of sunlight during the day.

Invariably, despite many myths, melatonin levels do not decrease in healthy aging individuals.

Receiving attention as a front-line sleep supplement, melatonin offers antioxidant and immune-stimulating mechanisms rivaling this benefit and more.

Multiple COVID-19 studies confirm melatonins powerful anti-inflammatory actions, while we see it in ICU use throughout the country.

Melatonin provides potent neuroprotection, gastroprotection, and cardioprotection against NLRP3 inflammasome progression of atherosclerosis, and lung, liver, and brain diseases.

More recent studies show melatonin can heal the gastrointestinal system in a variety of ways.

Decreasing nocturnal blood pressure by lowering norepinephrine, the blood pressure raising neurotransmitter is a notable melatonin benefit.

Blood pressure studies are showing nocturnal blood pressure is a vastly more important cardiovascular risk indicator than daytime blood pressure.

Melatonin Benefits:

  1. Anti-inflammatory
  2. Antioxidant
  3. Blood Pressure
  4. Cardiovascular Health
  5. Depression
  6. Eye Health
  7. Gastroesophageal Reflux Disorder (GERD)
  8. HGH
  9. Immune Stimulation
  10. Neuroprotection
  11. Weight Loss (Beige Fat Activation)

[References: 1,2,3,4,5,6,7,8,9]

Notes: Delayed-release melatonin performs best in studies, as we believe this action mimics our natural melatonin cycle.

Many believe the therapeutic antioxidant range is the 5 to 10 mg range.

This can be an adjustment, as it took me a few weeks to adjust to a 5 mg per night dosage.

Slowly increasing the dose to the 5–10 mg range might be the best strategy.

We should take melatonin roughly 2 hours prior to bedtime.

Cost: $13.66 for a 200 day supply at $.07 per day.


This is another low sex appeal supplement offering a huge return on investment.

The primary reason we might overlook the health value of lecithin is the lack of larger studies.

A medical professional, citing this objection, might not be operating with 100% intellectual honesty.

This is because, while we may not have large-scale lecithin studies, we do have an array of studies confirming the enormous health value of lecithin components.

Delivering substantial amounts of phosphatidylserine (PS), phosphatidylcholine (PC), and phosphatidylinositol (PI), lecithin is a powerful fat-like compound.

As a phospholipid or phosphatidylcholine, lecithin serves offers a notable B-vitamin, choline, and inositol source for improving overall health and the methylation process.

Additionally, lecithin offers us a source of phosphatidylserine and phosphatidylinositol, making it a mighty powerful health supplement.

Found mostly in the brain, heart, liver, and kidney, lecithin exists in every single cell in our body.

Lecithin is a naturally occurring essential fat in foods such as beef liver, cauliflower, eggs, oranges, peanuts, and steak.

Its ability to improve cholesterol and blood lipid metabolism is impressive.

Because of an array of associated benefits, medical professionals have used this as another reason to be “skeptical” of lecithin.

Lecithin Benefits Include:

  1. Cholesterol
  2. Heart Health
  3. Breastfeeding
  4. Digestion
  5. Dementia Symptoms
  6. Skin

[References: 10,11,12,13,14,15,16,17,18,19]

Notes: Lecithin is a dependable emulsifier that produces strong absorption enhancement.

Health optimizers can use it to increase the bio-availability of fat-soluble kava, kratom, or even CoQ10 or vitamin D.

The high absorption form of curcumin known as Meriva uses lecithin in its patented technology.

While there is no recommended dosage, a notable study showed tremendous benefits with as little as 500 mg per day.

Others suggest a range of 2,500 to 5,000 mg per day, while Dr. Andrew Saul suggests 7,500 per day.

Our suggestion is to always start low and slow.

Softgels are the most convenient route, unless for emulsification such as increasing kratom or kava potency, wherein we always suggest oil instead of powder.

Cost: $9.99 for a 100 day supply at $.10 per day for softgels.

Creatine (Micronized)

While our brain requires a considerable amount of ATP, creatine plays a critical role in brain function and health.

Powerful evidence exists for creatine supplementation, especially those with low levels.

This popular gym supplement is one of the most studied and proven supplements.

Creatine supplementation increases phosphocreatine stores in the brain which support ATP-energy levels.

Increasing mitochondrial function along with acetylcholine, dopamine, and serotonin levels, creatine is a serious body and brain supplement.

Supplement users are now combining creatine with d-ribose, another mitochondria booster, and cardioprotective supplement.

Besides significant mood benefits, we believe creatine improves cognition, not only through increased energy but likewise via neuroprotection.

More evidence continues emerging supporting creatine as much more than a popular workout supplement.

Creatine Benefits Include:

  1. Amyotrophic Lateral Sclerosis (ALS)
  2. ATP-Energy (Chronic Fatigue)
  3. Blood Sugar-Diabetes
  4. Brain-Spinal Injuries
  5. Dementia (Possibly Alzheimer’s)
  6. Depression
  7. Endurance
  8. Epilepsy
  9. High-Intensity Exercise
  10. Ischemic Stroke
  11. IGF-1
  12. Mitochondria Function
  13. Muscle Mass
  14. Neurological Decline
  15. Strength

[References: 20,21,22,23,24,25,26,27,28,29,30]

Notes: Creatine appears to be an area of deficiency and potential supplement target for vegans and women because of lower phosphocreatine brain levels.

Choose micronized creatine for better results and lower side effects.

5 grams per day is the typical dose.

I enjoy creatine with D-ribose before physical activity as part of my “energy and mood stack.”

Cost: $19.99 for a 200 day supply at $.10 per day.

Your Friend in Health

Mark Stein

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