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Superstar “Vitamin” for Blood Sugar and Cholesterol

(Understanding how a B-vitamin analog can improve your blood panels.)


Metabolic disease continues to be a worldwide health problem.

Whether dangerously high blood sugar (insulin resistance) or abnormal blood fats (high cholesterol), along with hypertension (high blood pressure), these conditions remain serious public health challenges.

Offering notable blood sugar and cholesterol improvement, these two B-vitamin analogs, deliver two meaningful options.

Benfotiamine and pantethine play a role in mitochondrial repair, supporting the body’s production of adenosine triphosphate (ATP), our primary energy source for most cellular processes.


While these two supplements can improve blood panels, they also ease symptoms such as diabetic neuropathy, without objectionable side effects.

As with all supplements, we should always consider diet and lifestyle changes for even better results.

Cold therapy, intermittent fasting, exercise (HIIT), and ketogenic diets have clinical evidence of mitochondrial support and repair.

Benfotiamine (Vitamin B1 Analog)

Fat-soluble, vitamin B1 analog, or derivative, benfotiamine displays a substantial increase in mitochondrial glucose oxidation, while reducing NOX4 gene expression.

This means benfotiamine is a powerful anti-diabetic compound, which works by facilitating a breakdown of sugar in the body.

As benfotiamine raises insulin levels in animal and cell studies, in humans it blocks the production of the sugar byproducts that cause diabetic issues, such as glycation end-products, or AGEs.

As we thiamine (vitamin B1), replicate these effects, benfotiamine offers a powerful solution for lowering blood sugar and diabetic nerve pain.

The most impressive studies on thiamine supplementation have used a fat-soluble form of thiamine known as benfotiamine.

The body absorbs Benfotiamine up to 3.6 times greater than vitamin B1, with a 120-fold greater increase in blood levels.

Its lipid solubility enables it to penetrate nerve membranes more efficiently than thiamine triphosphate (ThP).

Experimentally, benfotiamine reduces activation of inflammatory cytokines and transcription factors, including nuclear factor kappa-beta (NF-kb).

[Related Article: The Top 9 Science-Backed Blood Sugar Supplements]

Several impressive studies have shown that benfotiamine supplementation can reduce peripheral neuropathy symptoms and increase nerve conduction.

Most of these studies involved diabetic neuropathy.


For insulin resistance, (high blood sugar), combined with diabetic neuropathy, benfotiamine appears to be the single best supplement option. Studies use dosages of 150 to 300 mg 2 times per day for 6 to 24 weeks. We see the best results for nerve pain when combined with B6 and B12.


Pantethine (Vitamin B5 Analog)

As the analog or derivative of vitamin B5, pantothenic acid, pantethine is a cholesterol superstar supplement.

This water-soluble compound creates coenzyme A, (CoA), an essential cofactor in carbohydrate, lipid, and protein metabolism.

Effecting efficient cholesterol and fat storage in the liver, pantethine can influence healthier body fat distribution.

In moving fats and energy-creating mitochondria within the cells, the conversion of fats to energy is not possible without CoA.

Growing evidence shows pantethine significantly lowers LDL, triglycerides, total cholesterol, and lipid peroxidation while raising HDL.

This is remarkable considering pantethine improves all lipid targets while lowering cardiovascular disease and risk of death, with no toxicity nor side effects.

[Related Article: The Top 6 Science-Backed Cholesterol Supplements]

The best evidence supports its use for diabetics, triglycerides, and lipid peroxidation.

Besides cholesterol applications, pantethine is clinically effective for the prevention of inflammation, inhibition of platelets, immune system, cystinosis, gastrointestinal diseases, athletic performance, and even rheumatoid arthritis.


Studies use doses of 300 mg 2 to 3 times per day. While the studies are few, we see consistent and notable improvement with all cholesterol blood panel markers in 16 weeks. In animal studies, pantethine increases endogenous ketone body production, while providing a promising therapeutic for Parkinson’s dopamine-driven neuroprotection.


Your Friend in Health

Mark Stein

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